The fresh fidelity away from cell office is founded on brand new accumulation and you can ordered depletion from vital proteins government. From the creating brand new correctly timed, ubiquitin-founded proteolysis of mitotic regulating necessary protein securin, cyclin B, aurora A beneficial kinase, and you may polo-instance kinase step one, the newest anaphase promoting state-of-the-art/cyclosome (APC/C) ubiquitin ligase takes on an essential character into the keeping genomic balance. But not, zero full survey of one’s the amount of the misregulation during the cancers has been performed. Right here, we reviewed more 1600 ordinary and you may cancer tumors from the immunohistochemical staining out-of structure microarrays and found regular overexpression away from securin, polo-eg kinase 1, aurora A beneficial, and Skp2 in the malignant tumors. 자세히 보기